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Basic/Clinical Research

In addition to its clinical mission, the ALS Center at DHMC has an important research and education mission.

Basic, translational, clinical, and epidemiological research projects are being undertaken by a collaborative team of investigators. Every day clinicians, scientists, students, and patients are working to unravel the complexities of ALS and discover and test new therapies to treat it. This interdisciplinary and comprehensive approach is necessary to tackle challenging neurodegenerative diseases like ALS. In addition to the health professionals and scientists conducting these studies, the Center is training undergraduate and graduate students from Dartmouth College and The Geisel School of Medicine at Dartmouth to learn about ALS and have them help find a cure.

ALS Board Meeting Newsletter: Written by Emily Clough and Michael Jones

The following is a list of Neuromuscular research studies that are currently enrolling participants:

Neuromuscular Clinical Trials
A Phase 3, Multi-National, Double-Blind, Randomized, Placebo-Controlled, Stratified, Parallel Group, Study to Evaluate the Safety, Tolerability and Efficacy of Tirasemtiv in Patients with Amyotrophic Lateral Sclerosis (ALS)
A Phase 3, Open-Label Extension Study of Tirasemtiv for Patients with Amyotrophic Lateral Sclerosis (ALS) Who Completed VITALITY-ALS (CY 4031)
A Spatial Analysis of Florida, Ohio, New Hampshire, and Vermont
ALS in Northern NE
Controlled Trial of 3,4 Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (LEMS)
Detection of BMAA and Heavy Toxic Metals in Biospecimen
Northern New England Neurologic Biospecimen Repository
Pilot Study to Evaluate the Efficacy and Safety of Plasma Exchange with Albutein 5% in Patients with Amyotrophic Lateral Sclerosis
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