Restoration of thumb strength and function in basal joint arthritis: An observational comparative effectiveness trial

Principal Investigator

Vincent Pellegrini

Study Number

D20092

Summary

We propose a non-randomized longitudinal observational trial to study comparative effectiveness related to benefits (restoration of strength) and harms (sensory neuritis) associated with three commonly used procedures spanning the spectrum of surgical treatments for advanced thumb basal joint osteoarthritis. With a focus on longitudinal assessment of strength associated with biomechanical elements of basal joint reconstruction, this study will fill the knowledge gap regarding the incremental value of metacarpal stabilization, by ligament reconstruction or suture suspension, arthroplasty space preservation, and metacarpophalangeal (MCP) hyperextension in restoration of thumb function. We believe that thumb basal joint arthroplasty with metacarpal stabilization will provide greater improvement in grip and pinch strength, and better hand function, than might be achieved following provision of pain relief alone by simple trapeziectomy without metacarpal stabilization. The preservation of the arthroplasty space will positively correlate, and MCPJ hyperextension will negatively correlate, with improved thumb function, specifically lateral pinch strength.

Phase

III/IV

Available at the following location(s)

• Lebanon

View more details at ClinicalTrials.gov

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