Effects of hyperbaric oxygen therapy on the sinonasal microbiome
Principal Investigator
Study Number
STUDY02001297
Summary
Hyperbaric oxygen therapy, or the administration of 100% oxygen at greater than one atmosphere, has been used for the treatment of a variety of medical conditions and is thought to promote healing through improved oxygen delivery, promotion of growth factor synthesis, angiogenesis, and mitigation of inflammatory changes. This pilot study will provide novel data on how hyperbaric oxygen therapy impacts the olfactory cleft and overall objective olfactory function. Correlating changes in olfactory performance with alterations in the local mucosal cytokine environment and microbial dynamics of the olfactory cleft may provide mechanistic insight and potential therapeutic targets for future investigations. Applications of this pilot data may translate to further studies examining the role of hyperbaric oxygen therapy in diseased states such as chronic sinusitis, bacterial aggregates and biofilms of the upper respiratory tract, as well as post-viral olfactory dysfunction.
Phase
N/A
Contact
Available at the following location(s)
- Lebanon
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