Orthopaedics Research and Clinical Trials

Our orthopaedic researchers are developing new treatments and technologies to improve musculoskeletal care across the globe. These include:

  • Innovative surgical techniques
  • Advanced prosthetic technologies
  • Evidence-based treatment protocols

If you are interested, you may have the opportunity to take part in these research studies by joining a clinical trial.

In our research, we collaborate with other leading healthcare organizations to develop guidelines and protocols that shape orthopaedic care across the United States. Some of the institutions we work with include Johns Hopkins University, Mayo Clinic, and Cleveland Clinic.

Clinical trials

A clinical trial/study is research in which patients may volunteer to participate.  Clinical trials represent one of the final and most important steps in discovering better ways to prevent, diagnose, or treat orthopaedic conditions.

Our program is actively enrolling patients in multiple clinical trials across the health system. These studies evaluate the effectiveness of a treatment, medication, experimental drug, or device. Many of today’s standard therapies were made possible through prior clinical trial participation.

View the list of our current orthopaedic clinical trials. Consider joining a trial today; you could help change the future of medicine!

Current research

Orthopaedic oncology research

The Sarcoma Oncology Program at Dartmouth Cancer Center actively participates in clinical and basic science research that aims to improve the care of our patients.

Our program belongs to these cooperative groups:

These national and international research partnerships allow us access to enroll our patients in state-of-the-art clinical research trials here in the Upper Valley. We are currently enrolling in local, national, and international clinical trials.

Orthopaedic trauma and limb reconstruction research

The Orthopaedic Trauma and Limb Reconstruction team at Dartmouth is advancing the future of musculoskeletal care through a comprehensive research program that includes clinical trials, translational science, and foundational laboratory investigation across multiple institutions.

Our work focuses on improving outcomes for patients with complex fractures, limb-threatening injuries, fracture-related infection, and limb loss. These conditions demand innovation across surgery, biology, engineering, and rehabilitation.

Our research efforts have helped reshape standards of care in orthopaedic trauma and limb reconstruction by improving:

  • Infection prevention
  • Fracture healing
  • Limb salvage
  • Long-term functional recovery

By integrating clinical insight, scientific discovery, and collaborative innovation, our orthopaedic trauma research team are not only advancing knowledge but changing the future of care for patients locally, nationally, and worldwide.

Trauma and limb reconstruction collaborations and support

We are active participants in leading national and international research networks, including:

Through these collaborations, our investigators design and lead rigorously conducted studies that define best practices, evaluate emerging technologies, and translate scientific discovery into real-world clinical impact.

Our research portfolio is supported by competitive funding from:

  • The National Institutes of Health (NIH)
  • The U.S. Department of Defense (DoD)
  • The Patient-Centered Outcomes Research Institute (PCORI)